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Table 1 Clinico-pathologic characteristics according to disease stage and relapse (N = 126)

From: Intra-tumoural vessel area estimated by expression of epidermal growth factor-like domain 7 and microRNA-126 in primary tumours and metastases of patients with colorectal cancer: a descriptive study

Parameter

Stage of disease at time of operation

Stage II

Stage III

Stage IV

Relapse free

Relapsed

Relapse free

Relapsed

 

N = 20 (%)

N = 13 (%)

N = 20 (%)

N = 19 (%)

N = 54 (%)

Gender

     

  Male

12 (60)

7 (54)

9 (45)

10 (53)

22 (41)

  Female

8 (40)

6 (46)

11 (55)

9 (47)

32 (59)

Age

     

  Median

70

65

66

66

64

  Range

54-84

44-76

48-87

45-73

25-79

Location

     

  Colon

12 (60)

11 (85)

14 (70)

12 (63)

45 (83)

  Rectum

8 (40)

2 (15)

6 (30)

7 (37)

9 (17)

T category

     

  1-3

19 (95)

12 (92)

18 (90)

16 (84)

27 (50)

  4

1 (5)

1 (8)

2 (10)

3 (16)

27 (50)

Malignancy grade a

     

  High

3 (15)

2 (18)

5 (25)

2 (18)

12 (26)

  Low + medium

17 (85)

9 (82)

15 (75)

9 (82)

34 (74)

Vascular invasion a

     

  Yes

2 (11)

2 (22)

2 (11)

1 (13)

24 (55)

  No

16 (89)

7 (78)

17 (89)

7 (88)

20 (45)

Neuronal invasion a

     

  Yes

1 (10)

1 (11)

4 (20)

1 (13)

14 (42)

  No

9 (90)

8 (89)

16 (80)

7 (88)

19 (58)

EGFL7 VA b

     

  Median (95% CI)

2.9 (1.9-4.9)

5.0 (3.0-9.0)

3.0 (1.4-4.1)

6.0 (4.0-9.0)

7.0 (4.0-9.0)

miRNA-1276 VA

     

  Median (95% CI)

6.7 (5.6-9.9)

4.3 (4.0-8.9)

6.0 (4.0-8.0)

6.9 (4.8-11.8)

8.6 (5.3-10.8)

  1. CI: Confidence interval.
  2. aNot assessed for all patients.
  3. bEstimates of vessel area fraction.
  4. Not all numbers in the parentheses equal 100 due to rounding of data.
  5. The median, intra-tumoural EGFL7 VA was significantly higher in patients with relapsing disease compared to corresponding patients with stage II (p = 0.02) and stage III (p = 0.001), without relapse.
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