Figure 7
Protein expressions of apoptotic, anti-apoptotic and mitochondrial damage biomarkers in LV myocardium at 72 h after IR procedure. A) Protein expression of mitochondrial Bax in LV myocardium. p < 0.008, * vs. other groups with different symbols (*, †, ‡). B) Protein expression of cleaved caspase (Csp)-3 in LV myocardium. p < 0.001, * vs. other groups with different symbols (*, †, ‡). C) Protein expression of cleaved poly (ADP-ribose) polymerase (PARP) in LV myocardium. p < 0.01, * vs. other groups with different symbols (*, †, ‡). D) Protein expression of cytosolic cytochrome C (Cyto-Cyt C) in LV myocardium. p < 0.001, * vs. other groups with different symbols (*, †, ‡). E) Protein expression of Bcl-2 in LV myocardium. p < 0.01, * vs. other groups with different symbols (*, †, ‡). F) Protein expression of mitochondrial cytochrome C (Mito-Cyt C) in LV. p < 0.001, * vs. other groups with different symbols (*, †, ‡). All statistical analyses were performed by one-way ANOVA, followed by Bonferroni multiple comparison post hoc test (n = 8). Symbols (*, †, ‡) indicate significance (at 0.05 level). WT-SC = wide type sham control; WT-IR = wide type + ischemia reperfusion; DDP4D-SC = dipeptidyl peptidase-IV (DPP4) deficiency sham control; DDP4D-IR = DDP4D + ischemia reperfusion; WT-IR-Sita = wide type + ischemia reperfusion + sitagliptin.