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Figure 2 | Journal of Translational Medicine

Figure 2

From: Inhibition of dipeptidyl peptidase-IV enzyme activity protects against myocardial ischemia-reperfusion injury in rats

Figure 2

Histopathological findings of left ventricular (LV) myocardium at 72 h after IR procedure. A to E) Microscopic findings (100×) of Sirius red staining for identifying the collagen deposition in infarct area among five groups. F) Analytic results of collagen deposition, p < 0.0001, * vs. other groups with different symbols (*, †, ‡). Scale bars in right lower corner represent 100 μm. G to K) Microscopic findings (100×) of Masson's Trichrome staining for identifying the fibrotic area in LV myocardium. L) Analytic results of infarct area, p < 0.0001, * vs. other groups with different symbols (*, †, ‡). Scale bars in right lower corner represent 100 μm. All statistical analyses were performed by one-way ANOVA, followed by Bonferroni multiple comparison post hoc test (n = 8). Symbols (*, †, ‡) indicate significance (at 0.05 level). WT-SC = wide type sham control; WT-IR = wide type + ischemia reperfusion (IR); DDP4D-SC = dipeptidyl peptidase-IV (DPP4) deficiency sham control; DDP4D-IR = DDP4D + IR; WT-IR-Sita = wide type + IR + sitagliptin. HPF = high-power field.

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