Plasma mRNA expression levels of BRCA1 and TS as potential predictive biomarkers for chemotherapy in gastric cancer

Table 2 Sensitivity and specificity of plasma and tumor gene expression levels for the prediction of chemosensitivity

Gene expression	Chemotherapeutic agents	N	Optimal cut-off	Sensitivity	Specificity	AUC (95% CI)	P
Plasma
BRCA1	Docetaxel	123	0.76	63%	90%	0.77 (0.67-0.87)	<0.001
TS	Pemetrexed	136	1.01	71%	78%	0.78 (0.69-0.87)	<0.001
Tumor
BRCA1	Docetaxel	123	6.09	70%	79%	0.75 (0.66-0.84)	<0.001
TS	Pemetrexed	136	8.08	78%	79%	0.83 (0.76-0.90)	<0.001

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