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Table 2 Sensitivity and specificity of plasma and tumor gene expression levels for the prediction of chemosensitivity

From: Plasma mRNA expression levels of BRCA1 and TS as potential predictive biomarkers for chemotherapy in gastric cancer

Gene expression Chemotherapeutic agents N Optimal cut-off Sensitivity Specificity AUC (95% CI) P
Plasma        
  BRCA1 Docetaxel 123 0.76 63% 90% 0.77 (0.67-0.87) <0.001
  TS Pemetrexed 136 1.01 71% 78% 0.78 (0.69-0.87) <0.001
Tumor        
  BRCA1 Docetaxel 123 6.09 70% 79% 0.75 (0.66-0.84) <0.001
  TS Pemetrexed 136 8.08 78% 79% 0.83 (0.76-0.90) <0.001