Table 7 Univariate analysis of the association between expression levels of metabolism-related proteins in metastatic breast cancers and overall survival by the log-rank test

Glut-1

0.141

0.020

0.504

0.591

0.833

  Negative

121 (103–139)

102 (76–129)

94 (65–123)

84 (64–105)

131 (97–165)

  Positive

92 (72–111)

56 (41–70)

101 (74–127)

62 (35–88)

120 (89–150)

Hexokinase II

0.727

0.912

0.680

0.418

0.192

  Negative

112 (96–128)

83 (61–104)

103 (76–130)

85 (65–105)

146 (117–175)

  Positive

96 (68–124)

62 (42–81)

54 (42–65)

56 (21–90)

103 (69–137)

CAIX

0.044

<0.001

0.527

0.964

0.046

  Negative

115 (100–130)

87 (67–108)

115 (90–141)

81 (61–101)

140 (114–166)

  Positive

80 (56–103)

16 (0–41)

64 (42–86)

67 (30–105)

87 (49–124)

MCT4

0.612

0.787

0.995

0.652

0.456

  Negative

107 (87–128)

92 (62–122)

73 (29–117)

85 (63–107)

120 (85–154)

  Positive

113 (95–131)

66 (55–77)

107 (84–130)

61 (40–82)

138 (107–168)

GLS1

0.274

0.690

0.061

0.348

0.896

  Negative

114 (96–132)

85 (61–108)

133 (108–158)

70 (52–88)

127 (95–160)

  Positive

110 (91–130)

61 (43–78)

61 (43–80)

72 (47–98)

133 (102–164)

GDH

0.919

0.171

n/a

n/a

n/a

  Negative

165 (165–165)

165 (165–165)

n/a

n/a

n/a

  Positive

111 (97–125)

72 (58–86)

n/a

n/a

n/a

ASCT2

0.686

0.948

n/a

0.761

0.730

  Negative

111 (96–127)

89 (64–114)

n/a

83 (62–104)

135 (107–162)

  Positive

89 (74–104)

80 (47–114)

n/a

58 (40–76)

70 (57–83)

ATP synthase

0.965

0.171

n/a

n/a

n/a

  Negative

165 (165–165)

165 (165–165)

n/a

n/a

n/a

  Positive

111 (97–125)

72 (58–86)

n/a

n/a

n/a

SDHA

0.830

0.132

n/a

n/a

n/a

  Negative

165 (165–165)

165 (165–165)

n/a

n/a

n/a

  Positive

111 (96–125)

72 (57–86)

n/a

n/a

n/a

SDHB

0.460

0.630

0.372

0.870

0.649

  Negative

102 (80–124)

85 (52–118)

115 (85–146)

49 (45–53)

82 (48–115)

  Positive

117 (101–133)

68 (57–80)

70 (52–88)

80 (57–103)

135 (112–158)

PHGDH

0.590

0.494

0.878

0.048

0.939

  Negative

117 (96–138)

90 (61–119)

84 (53–115)

78 (65–90)

127 (80–174)

  Positive

108 (90–126)

60 (48–71)

107 (81–133)

64 (39–89)

122 (89–154)

PSPH

0.045

0.011

0.714

0.654

0.477

  Negative

114 (99–128)

88 (67–110)

108 (86–131)

83 (63–102)

131 (105–157)

  Positive

68 (36–100)

35 (22–49)

30 (17–42)

53 (22–83)

94 (41–147)

PSAT1

0.542

n/a

n/a

0.927

0.074

  Negative

109 (94–123)

n/a

n/a

83 (59–106)

134 (109–158)

  Positive

79 (63–95)

n/a

n/a

65 (46–83)

38 (11–65)

SHMT1

0.002

0.258

0.022

0.089

0.009

  Negative

119 (104–134)

84 (64–105)

117 (95–140)

90 (71–109)

147 (121–172)

  Positive

63 (31–94)

31 (7–56)

27 (19–34)

39 (24–55)

78 (32–123)

GLDC

0.281

0.485

0.024

0.281

0.370

  Negative

115 (98–133)

80 (55–104)

127 (105–150)

89 (68–111)

135 (102–168)

  Positive

99 (80–119)

66 (56–76)

53 (31–76)

59 (35–82)

111 (78–144)

Glycolysis type

0.615

0.159

0.614

0.921

0.961

  No

116 (97–134)

96 (71–122)

91 (59–123)

82 (61–103)

128 (91–164)

  Yes

99 (80–118)

63 (51–75)

102 (76–128)

69 (44–94)

123 (95–151)

Glutamine type

0.116

0.661

0.251

0.213

0.454

  No

121 (101–142)

90 (59–120)

128 (96–159)

74 (54–93)

140 (105–175)

  Yes

99 (79–119)

72 (51–93)

68 (51–84)

72 (49–95)

129 (101–157)

Mitochondrial type

0.830

0.132

n/a

n/a

n/a

  No

165 (165–165)

165 (165–165)

n/a

n/a

n/a

  Yes

111 (96–125)

72 (57–86)

n/a

n/a

n/a

Serine/glycine type

0.041

0.886

0.467

0.034

0.019

  No

116 (101–131)

83 (61–105)

109 (86–133)

90 (72–109)

142 (116–168)

  Yes

79 (56–103)

60 (45–76)

66 (30–103)

38 (15–60)

72 (32–112)

Molecular subtypes

0.002

<0.001

0.081

N/A

N/A

  Luminal A

105 (86–124)

84 (62–107)

55 (10–100)

N/A

N/A

  Luminal B

140 (111–170)

60 (26–93)

138 (112–164)

N/A

N/A

  HER-2

134 (109–158)

62 (47–77)

79 (60–97)

N/A

N/A

  TNBC

51 (38–64)

3 (2–4)

31 (22–39)

N/A

N/A