Table 4 Expression of metabolism-related proteins in the stromal compartment of breast cancer metastasis according to metastatic site
From: Site-specific metabolic phenotypes in metastatic breast cancer
Parameters | Total N = 162 (%) | Bone metastasis n = 47 (%) | Brain metastasis n = 39 (%) | Liver metastasis n = 24 (%) | Lung metastasis n = 52 (%) | p-value |
|---|---|---|---|---|---|---|
Hexokinase II | Â | Â | Â | Â | Â | 0.058 |
  Negative | 159 (98.1) | 44 (93.6) | 39 (100.0) | 24 (100.0) | 52 (100.0) |  |
  Positive | 3 (1.9) | 3 (6.4) | 0 (0.0) | 0 (0.0) | 0 (0.0) |  |
MCT4 | Â | Â | Â | Â | Â | 0.002 |
  Negative | 113 (69.8) | 26 (55.3) | 36 (92.3) | 17 (70.8) | 34 (65.4) |  |
  Positive | 49 (30.2) | 21 (44.7) | 3 (7.7) | 7 (29.2) | 18 (34.6) |  |
GLS1 | Â | Â | Â | Â | Â | 0.006 |
  Negative | 157 (96.9) | 42 (89.4) | 39 (100.0) | 24 (100.0) | 52 (100.0) |  |
  Positive | 5 (3.1) | 5 (10.6) | 0 (0.0) | 0 (0.0) | 0 (0.0) |  |
GDH | Â | Â | Â | Â | Â | 0.035 |
  Negative | 140 (86.4) | 36 (76.6) | 38 (97.4) | 22 (91.7) | 44 (84.6) |  |
  Positive | 22 (13.6) | 11 (23.4) | 1 (2.6) | 2 (8.3) | 8 (15.4) |  |
ATP synthase | Â | Â | Â | Â | Â | 0.084 |
  Negative | 155 (95.7) | 42 (89.4) | 38 (97.4) | 24 (100.0) | 51 (98.1) |  |
  Positive | 7 (4.3) | 5 (10.6) | 1 (2.6) | 0 (0.0) | 1 (1.9) |  |
SDHA | Â | Â | Â | Â | Â | 0.004 |
  Negative | 145 (89.5) | 36 (76.6) | 38 (97.4) | 21 (87.5) | 50 (96.2) |  |
  Positive | 17 (10.5) | 11 (23.4) | 1 (2.6) | 3 (12.5) | 2 (3.8) |  |
PHGDH | Â | Â | Â | Â | Â | 0.018 |
  Negative | 158 (97.5) | 43 (91.5) | 39 (100.0) | 24 (100.0) | 52 (100.0) |  |
  Positive | 4 (2.5) | 4 (8.5) | 0 (0.0) | 0 (0.0) | 0 (0.0) |  |
PSPH | Â | Â | Â | Â | Â | 0.006 |
  Negative | 156 (96.3) | 46 (97.9) | 34 (87.2) | 24 (100.0) | 52 (100.0) |  |
  Positive | 6 (3.7) | 1 (2.1) | 5 (12.8) | 0 (0.0) | 0 (0.0) |  |
PSAT1 | Â | Â | Â | Â | Â | <0.001 |
  Negative | 154 (95.1) | 46 (97.9) | 32 (82.1) | 24 (100.0) | 52 (100.0) |  |
  Positive | 8 (4.9) | 1 (2.1) | 7 (17.9) | 0 (0.0) | 0 (0.0) |  |
SHMT1 | Â | Â | Â | Â | Â | <0.001 |
  Negative | 98 (60.5) | 16 (34.0) | 31 (79.5) | 16 (66.7) | 35 (67.3) |  |
  Positive | 64 (39.5) | 31 (66.0) | 8 (20.5) | 8 (33.3) | 17 (32.7) |  |