Table 1 HPV16 E6 patient profile, clinical and immunological outcome
Pt | Age | Path | HPV type | Disease extension | # Vac | Off-Study response/reason | PFS (ms) | OS (ms) | Cr-51 | ELISPOT | IR |
|---|---|---|---|---|---|---|---|---|---|---|---|
1A | 39 | ACA | 18 | Mets | 8 | PD | 8.0 | 20.1 | - | + | + |
2A | 46 | SCC | 16 | Mets | 1 | SD/PPS | 0.7+ | 1.4 | ND | ND | ND |
3A | 41 | SCC | 18 | Mets | 6 | PD | 5.9 | 18.6 | - | - | - |
4A | 37 | SCC | 18 | Mets | 4 | PD | 3.6 | 9.7 | - | + | + |
5A | 47 | SCC | 18 | Mets | 2 | SD/PPS | 2.8+ | 4.9 | - | - | - |
6A | 36 | ASCC | 16 | Mets | 3 | PD | 1.6 | 8.7 | + | NA | + |
7A | 40 | ASCC | 18 | Mets | 4 | PD | 4.6 | 6.0 | - | - | - |
8A | 48 | ACA | 18 | Mets | 4 | PD | 3.4 | 10.0 | - | NA | - |
9A | 40 | SCC | 18 | Mets | 1 | SD/PPS | 4.4+ | 5.2 | ND | ND | ND |
10A | 43 | SCC | 18 | Mets | 2 | PD | 1.4 | 4.3 | - | + | + |
11A | 44 | ACA | 18 | Mets | 2 | PD | 1.5 | 4.9 | + | - | + |
12A | 53 | SCC | 18 | Mets | 2 | PD | 1.6 | 11.1 | - | + | + |
13A | 36 | SCC | 18 | Mets | 6 | PD | 5.6 | 10.7 | - | + | + |
14A | 36 | SCC | 18 | NED | 6 | PD | 5.3 | 20.5 | NA | - | - |
15A | 38 | SCC | 18 | NED | 10 | NED | 67.1+ | 67.1+ | - | + | + |
16A | 36 | SCC | 18 | Mets | 14 | SD | 115.9+ | 115.9+ | NA | + | + |
17A | 34 | SCC | 16 | Mets | 4 | PD | 0.4 | 3.9 | NA | + | + |
18A | 41 | SCC | 16 | Mets | 3 | PD | 1.5 | 3.7 | NA | - | - |