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Table 2 Mean and Standard deviation of the Combination Indexes (CI) of antibody pairs assayed against PV and T/F IMC, respectively

From: Synergy in monoclonal antibody neutralization of HIV-1 pseudoviruses and infectious molecular clones

 

PSEUDOVIRUS

T/F IMC

Average

 

Combination index

 

SF162

AC10. 0.29

REJO 4551.67

RHPA 4259.7

THRO 4156.18

REJO.c

RHPA.c

THRO.c

CH040.c

CH058.c

CH077.t

Pseudo

T/F

4E10 + 2F5

1.87* ± 0.59

0.79*** ± 0.17

1.12** ± 0.29

0.38 ± 0.11

-

1.76* ± 0.44

-

-

0.41 ± 0.3

-

-

1.04

1.08

4E10 + b12

0.32 ± 0.18

0.84*** ± 0.21

0.64 ± 0.13

0.18 ± 0.07

0.87*** ± 0.21

-

-

0.6 ± 0.17

0.016 ± 0.018

-

-

0.57

0.3

4E10 + 2G12

0.6 ± 0.25

-

-

-

-

-

-

-

-

-

-

0.6

n.d.

4E10 + PG9

-

0.455 ± 0.16

0.85*** ± 0.15

-

-

0.41 ± 0.07

-

-

-

-

-

0.65

0.41

4E10 + PG16

-

0.25 ± 0.14

0.61 ± 0.16

0.2 ± 0.07

-

0.35 ± 0.17

-

-

-

-

-

0.35

0.35

2F5 + b12

0.68*** ± 0.37

0.91** ± 0.19

0.58 ± 0.13

0.27 ± 0.09

-

-

-

-

0.36 ± 0.16

0.43 ± 0.15

-

0.61

0.39

2F5 + 2G12

0.82*** ± 0.49

-

-

-

-

-

-

-

-

0.31 ± 0.19

-

0.82

0.31

2F5 + PG9

-

0.54 ± 0.13

0.91** ± 0.2

-

-

0.66 ± 0.16

-

-

-

-

-

0.72

0.66

2F5 + PG16

-

0.22 ± 0.05

0.78*** ± 0.23

0.34 ± 0.09

-

0.38 ± 0.1

-

-

-

-

-

0.44

0.38

b12 + 2G12

0.72*** ± 0.72

-

-

-

-

-

-

-

-

0.48 ± 0.14

-

0.72

0.48

b12 + PG9

-

0.68 ± 0.2

1.02** ± 0.39

-

-

-

-

-

-

-

0.48 ± 0.14

0.85

0.48

b12 + PG16

-

0.29 ± 0.21

0.72 ± 0.09

0.31 ± 0.17

-

-

0.8*** ± 0.18

-

-

-

0.61*** ± 0.32

0.44

0.66

2G12 + PG9

-

-

-

-

-

-

-

-

-

-

-

n.d

n.d

2G12 + PG16

-

-

-

-

-

-

-

-

-

-

-

n.d

n.d

PG9 + PG16

-

0.38 ± 0.11

2.92* ± 0.54

-

-

0.93** ± 0.18

-

-

-

-

0.72*** ± 0.36

1.65

0.82

  1. *indicates CI values that indicate antagonism (n=3).
  2. **indicates CI values that fall in the range of additivity (n=5).
  3. ***indicates CI values that, due to the range of their standard deviations, fall into additivity and synergy (n=8).
  4. All remaining CI values fall only in the range of synergy (n = 34).
  5. Average CI of both group combinations are indicated in Italic.
  6. n.d. stands for not determined.