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Table 2 Mean and Standard deviation of the Combination Indexes (CI) of antibody pairs assayed against PV and T/F IMC, respectively

From: Synergy in monoclonal antibody neutralization of HIV-1 pseudoviruses and infectious molecular clones

  PSEUDOVIRUS T/F IMC Average
  Combination index
  SF162 AC10. 0.29 REJO 4551.67 RHPA 4259.7 THRO 4156.18 REJO.c RHPA.c THRO.c CH040.c CH058.c CH077.t Pseudo T/F
4E10 + 2F5 1.87* ± 0.59 0.79*** ± 0.17 1.12** ± 0.29 0.38 ± 0.11 - 1.76* ± 0.44 - - 0.41 ± 0.3 - - 1.04 1.08
4E10 + b12 0.32 ± 0.18 0.84*** ± 0.21 0.64 ± 0.13 0.18 ± 0.07 0.87*** ± 0.21 - - 0.6 ± 0.17 0.016 ± 0.018 - - 0.57 0.3
4E10 + 2G12 0.6 ± 0.25 - - - - - - - - - - 0.6 n.d.
4E10 + PG9 - 0.455 ± 0.16 0.85*** ± 0.15 - - 0.41 ± 0.07 - - - - - 0.65 0.41
4E10 + PG16 - 0.25 ± 0.14 0.61 ± 0.16 0.2 ± 0.07 - 0.35 ± 0.17 - - - - - 0.35 0.35
2F5 + b12 0.68*** ± 0.37 0.91** ± 0.19 0.58 ± 0.13 0.27 ± 0.09 - - - - 0.36 ± 0.16 0.43 ± 0.15 - 0.61 0.39
2F5 + 2G12 0.82*** ± 0.49 - - - - - - - - 0.31 ± 0.19 - 0.82 0.31
2F5 + PG9 - 0.54 ± 0.13 0.91** ± 0.2 - - 0.66 ± 0.16 - - - - - 0.72 0.66
2F5 + PG16 - 0.22 ± 0.05 0.78*** ± 0.23 0.34 ± 0.09 - 0.38 ± 0.1 - - - - - 0.44 0.38
b12 + 2G12 0.72*** ± 0.72 - - - - - - - - 0.48 ± 0.14 - 0.72 0.48
b12 + PG9 - 0.68 ± 0.2 1.02** ± 0.39 - - - - - - - 0.48 ± 0.14 0.85 0.48
b12 + PG16 - 0.29 ± 0.21 0.72 ± 0.09 0.31 ± 0.17 - - 0.8*** ± 0.18 - - - 0.61*** ± 0.32 0.44 0.66
2G12 + PG9 - - - - - - - - - - - n.d n.d
2G12 + PG16 - - - - - - - - - - - n.d n.d
PG9 + PG16 - 0.38 ± 0.11 2.92* ± 0.54 - - 0.93** ± 0.18 - - - - 0.72*** ± 0.36 1.65 0.82
  1. *indicates CI values that indicate antagonism (n=3).
  2. **indicates CI values that fall in the range of additivity (n=5).
  3. ***indicates CI values that, due to the range of their standard deviations, fall into additivity and synergy (n=8).
  4. All remaining CI values fall only in the range of synergy (n = 34).
  5. Average CI of both group combinations are indicated in Italic.
  6. n.d. stands for not determined.