Figure 5

Luciferase expression does not affect overall survival. Kaplan-Meier survival analysis (A) demonstrates no difference in overall survival for mice implanted intracranially with either GL261.luc (dashed line) or GL261 cells (solid line). One animal in the GL261.luc group was censored due to procedural-related death. In vivo quantitative bioluminescence imaging (B) demonstrates non-invasive monitoring of intracranial tumor growth in animals implanted with GL261.luc cells.