|
Parameter
|
LCI699 0.5 mg
|
LCI699 1 mg
|
LCI699 3 mg
|
Eplerenone
|
Placebo
|
|---|
|
n = 12
|
n = 12
|
n = 12
|
n = 10
|
n = 11
|
|---|
|
Age, years
|
33.0 ± 6.0
|
32.1 ± 7.2
|
34.2 ± 8.1
|
32.5 ± 5.2
|
35.8 ± 7.8
|
|
Body weight, kg
|
80.5 ± 6.1
|
76.1 ± 6.2
|
76.8 ± 6.9
|
79.2 ± 6.0
|
82.8 ± 8.6
|
|
Supine heart rate, bpm
|
57 ± 5
|
63 ± 10
|
61 ± 5
|
62 ± 9
|
64 ± 8
|
|
Supine blood pressure, mmHg
|
128/75 ± 8/7
|
124/73 ± 11/8
|
123/75 ± 8/4
|
124/73 ± 9/6
|
124/74 ± 9/6
|
|
Plasma aldosterone, pg/mL
|
204.8 ± 78.7
|
186.4 ± 74.5
|
236.1 ± 85.6
|
244.9 ± 80.3
|
224.2 ± 83.5
|
|
Plasma cortisol, ng/mL
|
120.5 ± 35.4
|
113.5 ± 28.2
|
112.9 ± 34.7
|
121.6 ± 46.1
|
103.4 ± 46.7
|
|
Plasma ACTH, pg/mL
|
21.9 ± 6.9
|
26.0 ± 9.6
|
30.7 ± 16.6
|
26.8 ± 14.1
|
22.1 ± 14.6
|
|
Plasma renin activity, ng/mL/h
|
1.24 ± 0.59
|
1.03 ± 0.65
|
1.00 ± 0.32
|
1.83 ± 1.36
|
1.30 ± 1.04
|
|
Plasma sodium, mmol/L
|
140.8 ± 1.4
|
140.9 ± 1.2
|
140.8 ± 1.4
|
141.2 ± 1.3
|
140.9 ± 2.1
|
|
Plasma potassium, mmol/L
|
4.5 ± 0.3
|
4.3 ± 0.2
|
4.5 ± 0.1
|
4.3 ± 0.3
|
4.3 ± 0.3
|
|
Serum creatinine, μmol/L
|
94.5 ± 6.5
|
93.1 ± 10.0
|
91.5 ± 6.3
|
90.6 ± 6.9
|
92.1 ± 4.4
|
|
Blood glucose, mmol/L
|
4.9 ± 0.5
|
4.9 ± 0.3
|
5.2 ± 0.5
|
5.2 ± 0.5
|
4.9 ± 0.7
|
- Values are mean ± SD unless otherwise stated.
