Figure 6

Effect of LCI699 on plasma and urinary aldosterone concentrations (human study, multiple-dose phase). Mean plasma aldosterone concentrations and percentage change in 24-hour urinary aldosterone from time-matched baseline on (A) Day 1, (B) Day 7 and (C) Day 14 of once-daily treatment with LCI699 (0.5, 1 or 3 mg), eplerenone (100 mg) or placebo in healthy human volunteers. Values are mean ± SEM. Number of evaluable subjects for LCI699 0.5, 1, 3 mg, eplerenone and placebo were (plasma) n = 12, 12, 12, 10 and 11 respectively, and (urine) n = 12, 9, 11, 9, 11. *P < 0.05, ^‡ P < 0.001 vs placebo.