Effect of LCI699 on survival in young dTG rats and older dTG rats with established cardiorenal disease. (A) Kaplan–Meier survival curves for young, male double-transgenic (dTG) rats (control) and dTG rats treated with LCI699 (3, 30 or 100 mg/kg/day) or eplerenone (30 mg/kg/day) in drinking water from 3 to 8 weeks of age. An additional group was treated continuously with 30 mg/kg/day for the duration of the study. Inset shows dose–median survival curves for LCI699 and eplerenone. (B) Kaplan–Meier survival curves for older male dTG rats with established cardiorenal disease who were pre-treated with enalapril (10 mg/kg/day in drinking water) from 3 to 8 weeks of age to slow the progression of disease. At 24 weeks of age, dTG rats had developed cardiorenal disease and were randomized to a control group (n = 8) or an LCI699 treatment group (30 mg/kg/day in drinking water) until moribundity or death. LCI699 prolonged survival in older dTG rats with established cardiorenal disease.