Figure 2

Effect of LCI699 on Ang-II- and ACTH-stimulated hormone release in rat and monkey in vivo models. (A) Dose–response plot and (B) exposure–response plot (8-h time-weighted average concentrations as percentage of baseline values) of effect of LCI699 on Ang-II stimulated plasma aldosterone and adrenocorticotropic hormone (ACTH)-stimulated plasma aldosterone and corticosterone in rats and (C) dose–response plot of effect of LCI699 on ACTH-stimulated plasma aldosterone and cortisol concentrations in monkeys. Values are mean ± SEM. Number of evaluable animals was n = 3 per dose group.