Structure of LCI699 (A) and in vitro inhibition of (B) aldosterone synthase (CYP11B2) and (C) 11β-hydroxylase (CYP11B1). (A) shows LCI699 phosphate salt. (B) shows Lineweaver–Burk plots of inhibition by LCI699 of human recombinant aldosterone synthase (CYP11B2) and 11β-hydroxylase (CYP11B1). Intersection of lines indicates competitive inhibition of both enzymes by LCI699 1 nmol/L. Values are mean ± SEM (n = 3 for all determinations). CYP, cytochrome P450.