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Figure 1 | Journal of Translational Medicine

Figure 1

From: Dendritic cell vaccines containing lymphocytes produce improved immunogenicity in patients with cancer

Figure 1

Adherence DCs elicit increased proliferation of lymphocytes post-vaccination. (A) 3H thymidine proliferation responses to prostate cancer cells lines, PC3, LNCaP or no antigen of lymphocytes from patients vaccinated with either Selected or Adherence DCs pulsed with PC3. CD14+ monocytes were used as APCs. Results are presented as average pre-vaccination counts per minute (CPM) subtracted from average post-vaccination CPM for each antigen group. The results are the average of 3 to 6 replicate wells. Black line indicates median. * indicates p < 0.05. NS = not statistically significant. (B) Pooled 3H thymidine proliferation responses to KLH or no antigen of lymphocytes from patients vaccinated with either Selected or Adherence DCs from 3 clinical trials. indicates response of patient in DC/LNCaP study, indicates response of patient in DC/PC3 study, and ■ indicates response of patient in DC pulsed with autologous brain tumor study.

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