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Table 1 Assessment schedule

From: Autologous bone marrow derived mesenchymal stromal cell therapy in combination with everolimus to preserve renal structure and function in renal transplant recipients

Baseline   Tx date Protocol renal biopsy First MSC infusion Second MSC infusion         
Week   D0 W4 a 5 W6 W7 W8 W9 W10 W12 W14 W16 W20 W24
BM harvesting   X            
MSC expansion, generating   X            
Informed consent X             
Medical history X X X X X X X X X X X X X
Concomitant medication X X X X X X X X X X X X X
Transplantation information X X X X X X X X X X X X X
Physical examination X X X X X X X X X X X X X
Routine lab X X X X X X X X X X X X X
Viral load CMV and BK   X X X   X   X   X   X X
Urinalysis X X X X X X X X X X X X X
MSC infusion     X X         
Renal biopsy   X X           X
Sera for storage   X X    X    X     X
Iohexol clearance    X           X
Blood for immune monitoring   X X X   X    X     X
DSA   X X#       X     X
Safety assessment X X X X X X X X X X X X X
Echo cardiography and pulse wave velocity    X           X
  1. Follow up study visits are planned at baseline, day of transplantation, during the renal biopsy (week 4 a 5), during the first and second MSC infusion at week 6 and 7, week 8, 9, 10, 12, 14, 16, 20, 24 after transplantation.
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