Validation of a hemoglobin A1c model in patients with type 1 and type 2 diabetes and its use to go beyond the averaged relationship of hemoglobin A1c and mean glucose level

Table 3 Results of estimation of the overall hemoglobin glycation rate constant ( k )

	Type 1 diabetes	Type 2 diabetes	All participants
	× 10⁻⁹(l mmol⁻¹ s⁻¹)
k based on BG according to WW method	1.294 ± 0.216 (0.964, 1.794)	1.298 ± 0.223 (1.016, 1.798)	1.296 ± 0.216 (0.964, 1.798)
k based on BG according to ID method	1.292 ± 0.222 (0.965, 1.794)	1.307 ± 0.220 (1.008, 1.787)	1.300 ± 0.217 (0.965, 1.794)
k calculated analytically based on MBG	1.300 ± 0.218 (0.977, 1.799)	1.313 ± 0.224 (1.024, 1.798)	1.306 ± 0.217 (0.977, 1.799)
Difference of k based on ID and WW methods	−0.002 ± 0.015 (−0.037, 0.035)	0.009 ± 0.031 (−0.033, 0.102)	0.003 ± 0.025 (−0.037, 0.102)
Difference of k calculated analytically and the one estimated using WW method	0.006 ± 0.010 (−0.009, 0.028)	0.014 ± 0.017 (−0.013, 0.050)	0.010 ± 0.014 (−0.013, 0.050)
Difference of k calculated analytically and the one estimated using ID method	0.008 ± 0.013 (−0.010, 0.036)	0.005 ± 0.033 (−0.100, 0.040)	0.007 ± 0.025 (−0.100, 0.040)

Data are mean ± SD (range).
k, overall hemoglobin glycation rate constant; BG, blood glucose concentration; WW method, 120-day glycemia was extrapolated based on two daily profiles for working days and for weekend obtained using the point-wise averaging; ID method, 120-day glycemia was extrapolated based on the glucose data with no averaging; MBG, mean blood glucose concentration.

ISSN: 1479-5876