Figure 6

HbA _1c in response to a ramp improvement (circles) and ramp deterioration (triangles) of glycemia. The improvement or deterioration of glycemia last for 120-day. In case of the improvement the initial glycemia is equal to: 8.3 mmol/l (white circles), 11.1 mmol/l (white triangles), 13.9 mmol/l (white squares), 16.7 mmol/l (white diamonds), 19.4 mmol/l (black circles) and 22.2 mmol/l (black triangles). The same hyperglycemic levels are used as the final glycemia in case of the ramp of deterioration of the glycemic control. In case of the improvement final glycemia is equal to 5.6 mmol/l and in case of the deterioration the initial glycemia is equal to 5.6 mmol/l. For two utmost lines error bars were calculated using the model with k at the boundaries of a 95% confidence interval (i.e. mean k ±1.96 × SD).