Figure 5

Changes of HbA _1c level in response to different simulated glycemic profiles. (A) HbA_1c in response to a step improvement of glycemia to 5.6 mmol/l in day zero; (B) HbA_1c in response to a step deterioration of glycemia from 5.6 mmol/l in day zero, (C) HbA_1c in response to hyperglycemia lasting for 30 days that ends in day zero (before day −30 and after day zero the glucose level is equal to 5.6 mmol/l). The following hyperglycemia levels were used: 8.3 mmol/l (white circles), 11.1 mmol/l (white triangles), 13.9 mmol/l (white squares), 16.7 mmol/l (white diamonds), 19.4 mmol/l (black circles) and 22.2 mmol/l (black triangles). For two utmost lines error bars were calculated using the model with k at the boundaries of a 95% confidence interval (i.e. mean k ±1.96 × SD).