Figure 4

Relationship of HbA _1c and the mean blood glucose level. Regression line (dashed line) of HbA_1c as a function of the mean blood glucose (MBG) obtained basing on 10,000 samples (the first exemplary 500 sampled data points are shown as black diamonds) drawn from the ADAG study population [2] (HbA _1c (%) = 0.5319 × MBG(mmol/L) + 2.419) in comparison with the linear regression obtained based on 25 pairs of MBG and corresponding HbA_1c values (white circles) simulated using the model of hemoglobin glycation, assuming the overall glycation rate constant (k) of 1.296 × 10⁻⁹ l mmol⁻¹ s⁻¹ and a constant life span of erythrocytes of 120 days (HbA _1c (%) = 0.5547 × MBG(mmol/L) + 2.4624). The dotted lines were calculated using the model with k at the boundaries of a 95% confidence interval (i.e. mean k ±1.96 × SD).