Figure 3

Effect of a subcutaneous administration of exendin-4 (30 nmol/kg) and/or exendin (9–39) (300 nmol/kg) on blood glucose levels following an intraperitoneal glucose load (1.5 g/kg, i.p.). (A) Blood glucose levels at t = −15 min to 120 min after administration of exendin (9–39) (300 nmol/kg) or saline (0.5 ml/kg) followed 15 min later by exendin-4 (30 nmol/kg) or saline (0.5 ml/kg) and a glucose load (1.5 g/kg, i.p.). (B) The area under the glycaemic curves between t = −15 and 0 min. (C) The area under the glycaemic curves between t =0 and 120 min. Sal = saline, Ex-4 = exendin-4, Ex-9 = exendin (9–39). 1. Ex-9 (300 nmol/kg, s.c.) or Sal (0.5 ml/kg, s.c.), 2. Ex-4 (30 nmol/kg, s.c.) or Sal (0.5 ml/kg, s.c.) + glucose (1.5 g/kg, i.p.). Data represents the mean ± s.e.m. of 3 animals. Significant differences are shown as *P <0.05, **P <0.01 (one-way ANOVA followed by Bonferroni test).