Figure 6
From: Berberine derivatives reduce atherosclerotic plaque size and vulnerability in apoE−/− mice
Effects of berberine and its derivatives on protein expression of inflammatory mediators in atherosclerotic plaques. ApoE−/− mice were fed with the Western diet for 16 weeks and then treated with BBR (b) or its derivatives, Di-MeBBR (c) and dhBBR (d) for 16 weeks. Mice receiving PBS served as the control group (a). Mouse aorta sections were collected. Representative immunostaining images and quantification of MMP-9 (A), ICAM-1 (B) and VCAM-1 (C) in atherosclerotic plaques. Scale bar represents 100 μm. *P < 0.05 vs. the control group.