Effects of berberine and its derivatives on CD68, EMMPRIN, and NFκB p65 protein expression in atherosclerotic plaques. ApoE−/− mice were fed with the Western diet for 16 weeks and then treated with BBR (b) or its derivatives, Di-MeBBR (c) and dhBBR (d) for 16 weeks. Mice receiving PBS served as the control group (a). Mouse aorta sections were collected. Representative immunostaining images and quantification of CD68 (A), EMMPRIN (B) and NFκB p65 (C) in atherosclerotic plaques. Scale bar represents 100 μm. *P < 0.05 vs. the control group.