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Table 1 Baseline parameters of isolated heart experiments

From: Cardioprotective efficacy depends critically on pharmacological dose, duration of ischaemia, health status of animals and choice of anaesthetic regimen: a case study with folic acid

Group Flow (ml/min/g) EDP (mmHg) Psys (mmHg) Heart rate (beats/min) RPP(103 mmHg/min)
WT, 25 min I, 0 FA 12.7 ± 0.3 8.0 ± 0.7 99 ± 9 366 ± 3 33.4 ± 3.3
WT, 25 min I, 1 FA 10.9 ± 0.2 8.0 ± 0.8 91 ± 2 415 ± 27 34.3 ± 1.6
WT, 25 min I, 5 FA 9.2 ± 0.3 7.0 ± 0.4 95 ± 6 364 ± 14 32.1 ± 3.2
WT, 25 min I, 50 FA 10.2 ± 0.7 7.3 ± 0.2 102 ± 4 366 ± 24 35.1 ± 3.5
WT, 35 min I, 0 FA 12.0 ± 0.5 4.4 ± 0.7 119 ± 4 356 ± 12 40.6 ± 1.9
WT, 35 min I, 5 FA 12.4 ± 1.0 6.0 ± 0.3 114 ± 4 346 ± 26 36.8 ± 1.7
WT, 35 min I, 50 FA 11.7 ± 1.4 5.0 ± 1.1 121 ± 7 382 ± 9 44.2 ± 2.9
WT, 35 min I, 100 FA 10.1 ± 0.7 5.7 ± 1.2 107 ± 3 347 ± 20 35.6 ± 3.2
eNOS−/−, 25 min I, 0 FA 12.7 ± 1.4 5.1 ± 1.9 113 ± 6 383 ± 24 41.8 ± 4.8
eNOS−/−, 25 min I, 50 FA 11.0 ± 1.4 5.2 ± 0.6 107 ± 6 356 ± 29 36.7 ± 3.9
  1. WT, wild-type; 0-1- 5-50-100 FA, 0-1-5-50-100 μM Folic Acid; ml/min/g, ml perfusate per min per g heart wet weight; EDP, end-diastolic pressure; Psys, peak systolic pressure; RPP, rate pressure product. No differences among groups were detected. Mean ± SEM.