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Figure 4 | Journal of Translational Medicine

Figure 4

From: Cardioprotective efficacy depends critically on pharmacological dose, duration of ischaemia, health status of animals and choice of anaesthetic regimen: a case study with folic acid

Figure 4

No protection against 25 min I and 45 min R with FA in eNOS −/− -isolated perfused mouse hearts. (A) Cumulative lactate dehydrogenase (LDH) release during 45 min R (index of cell death) in groups treated with different FA doses; (B) End-diastolic pressure (EDP) at end R for the different groups of FA treatment; (C) % Rate-pressure product (RPP) determined at end R and normalised to baseline, pre-ischaemic, values for the different groups. (n = 7 hearts per group). Mean ± SEM.

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