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Figure 2 | Journal of Translational Medicine

Figure 2

From: Cardioprotective efficacy depends critically on pharmacological dose, duration of ischaemia, health status of animals and choice of anaesthetic regimen: a case study with folic acid

Figure 2

No protection against 35 min I and 45 min R with increasing doses of FA in isolated perfused mouse hearts. (A) Cumulative lactate dehydrogenase (LDH) release during 45 min R (index of cell death) in groups treated with different FA doses; (B) End-diastolic pressure (EDP) at end R for the different groups of FA treatment; (C) % Rate-pressure product (RPP) determined at end R and normalised to baseline, pre-ischaemic, values for the different groups. (n = 3-6 hearts per group). Mean ± SEM, * P < 0.05 vs. FA = 0 group.

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