Figure 2

Effect of Immunomax ® on immune effector and suppressor cells. Immunomax® increased the frequency of activated effector cells [NK (A, ***P < 0.001), CD4⁺ (B, ***P = 0.0001) and CD8⁺ (C, **P = 0.0033)] and reduced the frequency of GR1⁺CD11b⁺ MDSC (D, *P < 0.05) without changing the levels of Treg cells among CD4⁺ cell population (E) in spleens of treated 4T1 tumor-resected mice (n = 18) compared with control mice (n = 19). Representative FACS images are presented. Numbers indicate the percentage of cells in a quadrant.