Table 2 Association of RFC4 protein expression with clinicopathologic characteristics in CRC

Sex

0.059

Female

147

59 (40.1%)

88 (59.9%)

Male

184

93 (45.9%)

91 (54.1%)

Age

0.301

≤60

167

72 (43.1%)

95 (56.9%)

>60

164

80 (48.8%)

84 (51.2%)

Tumor location

0.344

Colon

154

75 (48.7%)

79 (51.3%)

Rectal

177

77 (43.5%)

100 (56.5%)

Differentiation

0.004

Well/Moderate

299

145 (48.5%)

154 (51.5%)

Poorly

32

7 (21.9%)

25 (78.1%)

Preoperative CEA level

0.656

< 5 ng/ml

194

89 (45.9%)

105 (54.1%)

≥ 5 ng/ml

111

48 (43.2%)

63 (56.8%)

Preoperative CA19-9 level

0.560

< 37 U/ml

238

109 (45.8%)

129 (54.2%)

≥37 U/ml

67

28 (41.8%)

39 (58.2%)

pT (invasion depth)

0.479

T1

6

1 (16.7%)

5 (83.3%)

T2

54

27 (50.0%)

27 (50.0%)

T3

233

106 (45.5%)

127 (54.5%)

T4

38

18 (47.4%)

20 (52.6%)

pN (lymph node metastasis)

0.055

N0

197

99 (49.2%)

98 (50.8%)

N1-2

134

53 (46.3%)

81 (53.7%)

pM (distant metastasis)

0.795

M0

299

138 (46.2%)

161 (53.8%)

M1

32

14 (43.8%)

18 (56.2%)

TNM stage

0.036

I + II

193

98 (50.8%)

95 (49.2%)

III + IV

138

54 (39.1%)

84 (60.9%)