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Table 2 Association of RFC4 protein expression with clinicopathologic characteristics in CRC

From: Levels of human replication factor C4, a clamp loader, correlate with tumor progression and predict the prognosis for colorectal cancer

Characteristics Cases RFC4 expression Pvalue
Normal expression Overexpression
Sex     0.059
Female 147 59 (40.1%) 88 (59.9%)  
Male 184 93 (45.9%) 91 (54.1%)  
Age     0.301
≤60 167 72 (43.1%) 95 (56.9%)  
>60 164 80 (48.8%) 84 (51.2%)  
Tumor location     0.344
Colon 154 75 (48.7%) 79 (51.3%)  
Rectal 177 77 (43.5%) 100 (56.5%)  
Differentiation     0.004
Well/Moderate 299 145 (48.5%) 154 (51.5%)  
Poorly 32 7 (21.9%) 25 (78.1%)  
Preoperative CEA level     0.656
< 5 ng/ml 194 89 (45.9%) 105 (54.1%)  
≥ 5 ng/ml 111 48 (43.2%) 63 (56.8%)  
Preoperative CA19-9 level     0.560
< 37 U/ml 238 109 (45.8%) 129 (54.2%)  
≥37 U/ml 67 28 (41.8%) 39 (58.2%)  
pT (invasion depth)     0.479
T1 6 1 (16.7%) 5 (83.3%)  
T2 54 27 (50.0%) 27 (50.0%)  
T3 233 106 (45.5%) 127 (54.5%)  
T4 38 18 (47.4%) 20 (52.6%)  
pN (lymph node metastasis)     0.055
N0 197 99 (49.2%) 98 (50.8%)  
N1-2 134 53 (46.3%) 81 (53.7%)  
pM (distant metastasis)     0.795
M0 299 138 (46.2%) 161 (53.8%)  
M1 32 14 (43.8%) 18 (56.2%)  
TNM stage     0.036
I + II 193 98 (50.8%) 95 (49.2%)  
III + IV 138 54 (39.1%) 84 (60.9%)