Figure 2

Clustering analysis of familial breast tumors. A) Unsupervised hierarchical clustering of fFBCs (BRCA-related and BRCAX) and FMBCs over 53 deregulated miRNAs (Pink indicates overexpressed miRNAs; blue indicates underexpressed miRNAs); B) Bootstrap analysis of the sample set by Consensus Clustering. Plot shows change in Gini correlation coefficient (ΔGn) with each additional group added, indicating that the optimal numbers of clusters is three; C) Red squares in the consensus matrix represent the subgroup of the sample set. fMBC: familial male breast cancer; fFBC: familial female breast cancer.