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Table 3 Multivariate analysis of prognostic factors

From: Specific-detection of clinical samples, systematic functional investigations, and transcriptome analysis reveals that splice variant MUC4/Y contributes to the malignant progression of pancreatic cancer by triggering malignancy-related positive feedback loops signaling

Variable Forward stepwise Backward stepwise
  HRa(95% CIb) p HR (95% CI) p
Location of tumor   0.085   0.001*
 Head -   1  
 Body and tail -   2.452 (1.414-4.253)  
Differentiation   0.001*   <0.001*
 Well 1   1  
 Moderate 2.368 (1.120-5.007) 0.024* 2.163 (0.994-4.706) 0.052
 Poor 6.603 (2.515-17.338) <0.001* 7.076 (2.655-18.857) <0.001*
TNM staging   0.175   0.014*
 IA + IB -   1  
 IIA - 0.929 3.395 (1.414-8.148) 0.006*
 IIB - 0.922 3.551 (1.523-8.277) 0.003*
 III + IV - 0.077 4.218 (1.652-10.768) 0.003*
Serum CA19-9 (kU/L)   0.021*   0.008*
 ≤ 39 1   1  
 > 39 1.914 (1.105-3.318)   2.817 (1.313-6.043)  
Serum CA50 (kU/L)   0.535   0.085
 ≤ 25 -   1  
 > 25 -   0.552 (0.280-1.086)  
Serum CEA (μg/L)   0.265   0.089
 ≤ 4.3 -   1  
 > 4.3 -   1.554 (0.934-2.584)  
MUC4 (2-ΔCt)   0.001*   0.010*
 Low (<0.056) 1   1  
 High (≥0.056) 2.281 (1.415-3.677)   1.976 (1.174-3.326)  
MUC4/Y (2-ΔCt)   0.067   0.243
 Low (<0.0044) -   -  
 High (≥0.0044) -   -  
  1. aHR, hazard ratio; bCI, confidence interval; * p <0.05.