Figure 2

Direct effects of lung cancer cells on peripheral blood mononuclear cells (PBMCs) measured during the co-culture of PBMCs from healthy donors with lung cancer cells (A549). A: Frequency of CD4⁺ T cells in total PBMCs, B: Frequency of CD19⁺ B cells in total PBMCs, C: Frequency of Tregs in CD4⁺ T cells, D: Frequency of CD45RA⁺Tregs in CD4⁺ T cells, E: Frequency of CD19⁺CD24^hiCD27⁺ B cells in CD19⁺ B cells, and F: Frequency of CD19⁺IL-10⁺ B cells in CD19⁺ B cells. *, **, and *** stand for p value less than 0.05, 0.01, and 0.001, as compared to PBMCs alone, respectively.