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Table 4 Comparison of intracellular molecules between patients with systemic lupus erythematosus and disease controls

From: Investigation of the caspase-dependent mitochondrial apoptotic pathway in mononuclear cells of patients with systemic lupus erythematosus

  SLE Disease controls  
  n = 31 n = 15 p value
Intracellular protein levels    
  MDA5 (pg/mL) 701.53 (543.45,885.96) 296.74 (216.50,567.40) <0.01*
  Activated caspase 9 9.74 (0.81, 22.34) 2.20 (0.26, 3.58) 0.06
  Activated caspase 10 0.77 (0.51, 2.09) 0.15 (0.04, 0.24) <0.01*
  pIRF7 0.10 (0.04, 0.30) 0.03 (0.01, 0.04) <0.01*
  Activated MAVS 0.82 (0.19, 2.59) 0.24 (0.11, 0.42) 0.02*
  1. Data presented with median, IQR; IQR, inter-quartile range.
  2. The levels of pIRF7, activated caspase 9, caspase 10, and MAVS from Western blot method were normalized with actin levels.
  3. Abbreviation: pIRF7, phosphorylated interferon regulator factor 7; MAVS, mitochondrial anti-viral signaling protein.
  4. *p < 0.05.