Table 2 Mutations found in 37 SDCs by AmpliSeq
From: High-throughput profiling identifies clinically actionable mutations in salivary duct carcinoma
Gene | Accession | Number of mutations | Mutations |
|---|---|---|---|
APC | NM_000038 | 8 | G1106R, A1347T, P1361L, E1374K, Q1378X, S1434N, G1466E, H1490Y |
ATM | NM_000051 | 3 | E848K, D1693N, A1742V |
EGFR | NM_005228 | 7 | V765M, A859T, A864V, E865K, E866K, A871T, G874S |
ERBB2 | NM_004448 | 4 | I767M, D769Y, G776V, V842I |
ERBB4 | NM_005235 | 5 | A287T, S341L, D609N, R612Q, P619L |
FBXW7 | NM_033632 | 3 | G391D, D440N, R441W |
HRAS | NM_176795 | 2 | G13S, Q61R |
KIT | NM_000222 | 7 | D496N, M541L, W557X, E561K, W582X, A636V, A637F |
KRAS | NM_004985 | 4 | G15S, T35I, E49K, E63K |
MET | NM_000245 | 1 | N375S |
PIK3CA | NM_006218 | 15 | E65K, R88X, R108H, E110K, S326F, V344M, D350N, E542K, E545K, D1018N, A1020T, E1037K, M1043I, H1047R, G1049D |
PTEN | NM_000314 | 10 | W111X, D115N, G132S, M134I, R233X, R234Q, Q245X, E256K, T319fs, P339L |
SMAD4 | NM_005359 | 10 | Q116X, R135X, Q256X, P356S, P356L, R496H, R497H, C499Y, W509X, R531W |
STK11 | NM_000455 | 4 | Q170X, G171S, P281L, F354L |
TP53 | NM_001126112 | 33 | A78V, P80L, A86V, S95F, V97A, P98L, R110C, S127fs, P128fs, K132R, C135W, V157G, R181C, Q192X, H193Y, R213Q, S215R, P219S, P223S, G226D, S241F, V272G, R273C, A276D, D281N, R282W, E285K, E286G, E287K, R290H, G293R, G302E, E339K |