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Figure 5 | Journal of Translational Medicine

Figure 5

From: Dual effects of a targeted small-molecule inhibitor (cabozantinib) on immune-mediated killing of tumor cells and immune tumor microenvironment permissiveness when combined with a cancer vaccine

Figure 5

Cabozantinib alters the tumor infiltration of negative regulatory cell subsets. A portion of the tumors depicted in Figure 4 were homogenized into a single-cell suspension and analyzed by flow cytometry for the presence of (A) Tregs (CD3+CD4+CD25+FoxP3+), (B) MDSCs (CD11b+Gr-1+), and (C) TAMs (CD11b+Gr-1+). Statistical analyses were done by Kolmogorov-Smirnov test. * = P <0.01 upregulation relative to control. ** = P <0.01 downregulation relative to control.

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