MicroRNA regulation in human CD8+ T cell subsets – cytokine exposure alone drives miR-146a expression

Table 1 P values for miRNAs significantly differentially expressed when comparing naïve to Tcm or Tem subsets

miRNAs up-regulated with differentiation
	Tcm-naive	Tem-naive	Tem-Tcm
hsa-miR-146a	0.010	0.075	0.447
hsa-miR-221	0.023	0.130	0.737
hsa-miR-222	0.023	0.056	0.912
hsa-miR-23a	0.030	0.008	0.773
hsa-miR-24	0.046	0.005	0.413
hsa-miR-15a	0.742	0.041	0.457
hsa-miR-22	0.521	0.043	0.532
hsa-miR-28-5p	0.668	0.044	0.518
hsa-miR-663	0.340	0.034	0.600
miRNAs down-regulated with differentiation
	Tcm-naive	Tem-naive	Tem-Tcm
hsa-miR-181a	0.006	0.006	0.800
hsa-miR-874	0.013	0.006	0.929
hsa-miR-92a	0.014	0.013	0.983
hsa-miR-378	0.015	0.015	0.973
hsa-miR-151-5p	0.015	0.005	0.651
hsa-miR-502-3p	0.015	0.152	0.518
hsa-miR-181b	0.021	0.040	0.936
hsa-miR-320d	0.022	0.009	0.912
hsa-miR-181c	0.022	0.034	0.976
hsa-miR-146b-3p	0.023	0.012	0.951
hsa-miR-342-3p	0.027	0.059	0.929
hsa-miR-1271	0.028	0.619	0.457
hsa-miR-146b-5p	0.032	0.093	0.902
hsa-miR-324-3p	0.038	0.362	0.651
hsa-miR-1275	0.040	0.609	0.518
hsa-miR-194	0.044	0.072	0.975
hsa-miR-342-5p	0.048	0.146	0.903
hsa-miR-20b	0.052	0.038	0.981
hsa-miR-192	0.157	0.034	0.814
hsa-miR-31	0.950	0.009	0.167

p values are shown for miRNAs that were statistically significantly up or down regulated when comparing naïve cells to either the Tcm or Tem subsets using Affymetrix miRNA microarrays.
Figures in bold represent p values <0.05.

ISSN: 1479-5876