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Table 1 Summary of selected adverse events reported with immune checkpoints inhibitors

From: The role of immunotherapy in solid tumors: report from the Campania Society of Oncology Immunotherapy (SCITO) meeting, Naples 2014

Category

Adverse events

Common

Skin

Pruritus, rash, vitiligo, urticaria, alopecia, macular rash, hypopigmentation, erytema, erytematous rash

Gastrointestinal

Diarrhea, colitis, nausea, abdominal pain

Endocrine

Hypothyroidism, hyperthyroidism, hypopituitarism, hypophysitis, adrenal insufficiency, altered hormone levels

Hepatic

Hepatitis, increased liver function enzymes

Pulmonary

Pneumonitis, pulmonary edema

Uncommon

Ocular

Uveitis, episcleritis, eye pruritus

Pancreatic

Elevated lipase levels, hyperglycemia

Infusion-related

Infusion-related reactions, hypersensitivity reactions

Hematologic

Anemia, leukocytosis, thrombocytopenia

Neurologic

Peripheral neuropathies, headache

General

Fatigue, decreased appetite, arthralgia