Figure 5
Histology of fore paws from CAIA in Tg1278TNFko animals. Arthritis was induced by i.p. injection of 8mg collagen II antibody cocktail (CAb) on Day 0 and 10μg LPS i.p. 1 day later. Joints were taken on Day 14. A, C and E, haematoxylin and eosin, B, D and F, toluidine blue. Compared with normal paws (A and B), arthritic paws (C and D) show infiltration with inflammatory cells and erosion of cartilage and bone. The effect of treating with etanercept at 30mg/kg is shown in e and f. Inflammatory cell influx is reduced and there is no cartilage or bone erosion.