Figure 4

Effects of etanercept on CAIA in Tg1278TNFko animals. Arthritis was induced in male and female mice by i.p. injection of 8 mg collagen II antibody cocktail (CAb) on Day 0 followed by 10 μg LPS i.p. 1 day later. A shows the effects of dosing etanercept at 0.03, 0.3, 3 or 30 mg/kg i.v. for the first dose with subsequent doses s.c. from 6 hours post LPS administration with individual animal data expressed as area under curve (AUC) arthritis score shown in B. C, shows the effects of etanercept dosing at 30 mg/kg from 6 hours, 2 days or 4 days post LPS with individual animal data shown in D. Data are means +/- s.e.m., n = 8/group. *p < 0.05, **p < 0.01, ***p < 0.001 comparison with the vehicle control group.