Figure 2

CAIA in Tg1278TNFko animals in the presence or absence of LPS challenge. Arthritis was induced in male mice by i.p. injection of 2, 4 or 8 mg collagen II antibody cocktail (CAb) on Day 0. The effects of administering 10 μg LPS i.p. 4 days later on arthritis scores are shown in A, and on bodyweights in B. C, shows arthritis scores in the absence of LPS challenge and D shows effects on bodyweight. Data are means +/- s.e.m., n = 5-7/group.