Table 1 The experimental design and related treatment was as follows
Group no. | Surgery | Treatment | Dose and duration |
|---|---|---|---|
1 | sham | vehicle | saline and two months |
2 | ligature | vehicle | saline and two months |
3 | OVX + ligature | vehicle | saline and two months |
4 | OVX + ligature | local simvastatin | 0.8 mg/0.05 mL and two months |
5 | OVX + ligature | oral simvastatin | 25 mg/kg and two months |
6 | OVX + ligature | local and oral simvastatin | 0.8 mg/0.05 mL, 25 mg/kg and two months |