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Table 3 The diagnostic efficacies of the E2/E6E7 and multiple E1-L1/E6E7 ratio analyses in relation to DIPS

From: Diagnosis of 25 genotypes of human papillomaviruses for their physical statuses in cervical precancerous/cancerous lesions: a comparison of E2/E6E7 ratio-based vs. multiple E1-L1/E6E7 ratio-based detection techniques

DIPS E2/E6E7 ratio analysis* E2-L1/E6E7 ratio analysis*
Positive Negative Positive Negative
All women (1162 cases)
positive (n = 357) 270 (75.6) 87 (24.4) 331 (92.7) 26 (7.3)
negative (n = 805) 6 (0.7) 799 (99.3) 8 (1.0) 797 (99.0)
Women in the highest tertile (387 cases, viral DNA load ≥ 36.7 copies/cell) §
positive (n = 69) 31 (44.9) 38 (55.1) 52 (75.4) 17 (24.6)
negative (n = 318) 2 (0.6) 316 (99.4) 2 (0.6) 316 (99.4)
Women in the middle tertile (387 cases, 12.7 copies/cell ≤ viral DNA load < 36.7 copies/cell) §
Positive (n = 123) 97 (78.9) 26 (21.1) 118 (95.9) 5 (4.1)
negative (n = 264) 2 (0.8) 262 (99.2) 2 (0.8) 262 (99.2)
Women in the lowest tertile (388 cases, viral DNA load <12.7 copies/cell) §
positive (n = 165) 142 (86.1) 23 (13.9) 161 (97.6) 4 (2.4)
negative (n = 223) 2 (0.9) 221 (99.1) 4 (1.8) 219 (98.2)
  1. *The data are presented as numbers (%).
  2. The positive cases include both the mixed and integrated HPV infection cases that were detected by the copy number ratio-based techniques.
  3. The negative cases indicate the episomal HPV infection cases that were detected by the copy number ratio-based techniques.
  4. §The women were divided into tertiles according to their viral DNA loads as determined by real-time PCR in the cervical samples.