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Table 3 The diagnostic efficacies of the E2/E6E7 and multiple E1-L1/E6E7 ratio analyses in relation to DIPS

From: Diagnosis of 25 genotypes of human papillomaviruses for their physical statuses in cervical precancerous/cancerous lesions: a comparison of E2/E6E7 ratio-based vs. multiple E1-L1/E6E7 ratio-based detection techniques

DIPS

E2/E6E7 ratio analysis*

E2-L1/E6E7 ratio analysis*

Positive†

Negative‡

Positive†

Negative‡

All women (1162 cases)

positive (n = 357)

270 (75.6)

87 (24.4)

331 (92.7)

26 (7.3)

negative (n = 805)

6 (0.7)

799 (99.3)

8 (1.0)

797 (99.0)

Women in the highest tertile (387 cases, viral DNA load ≥ 36.7 copies/cell) §

positive (n = 69)

31 (44.9)

38 (55.1)

52 (75.4)

17 (24.6)

negative (n = 318)

2 (0.6)

316 (99.4)

2 (0.6)

316 (99.4)

Women in the middle tertile (387 cases, 12.7 copies/cell ≤ viral DNA load < 36.7 copies/cell) §

Positive (n = 123)

97 (78.9)

26 (21.1)

118 (95.9)

5 (4.1)

negative (n = 264)

2 (0.8)

262 (99.2)

2 (0.8)

262 (99.2)

Women in the lowest tertile (388 cases, viral DNA load <12.7 copies/cell) §

positive (n = 165)

142 (86.1)

23 (13.9)

161 (97.6)

4 (2.4)

negative (n = 223)

2 (0.9)

221 (99.1)

4 (1.8)

219 (98.2)

  1. *The data are presented as numbers (%).
  2. †The positive cases include both the mixed and integrated HPV infection cases that were detected by the copy number ratio-based techniques.
  3. ‡The negative cases indicate the episomal HPV infection cases that were detected by the copy number ratio-based techniques.
  4. §The women were divided into tertiles according to their viral DNA loads as determined by real-time PCR in the cervical samples.