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Table 2 The age-related distributional characteristics and physical statuses of the 25 HPV genotypes detected*

From: Diagnosis of 25 genotypes of human papillomaviruses for their physical statuses in cervical precancerous/cancerous lesions: a comparison of E2/E6E7 ratio-based vs. multiple E1-L1/E6E7 ratio-based detection techniques

HPV genotypes

Age groups (years)†

Physical statuses‡

20-24 (n = 66)

25-29 (n = 207)

30-34 (n = 262)

35-39 (n = 235)

40-44 (n = 212)

45-49 (n = 121)

50-54 (n = 41)

55-59 (n = 11)

60-64 (n = 5)

65-69 (n = 2)

Episomal (n = 805)

Integrated/Mixed§(n = 357)

HPV 6

2 (3.0)

4 (1.9)

12 (4.6)

2 (0.9)

2 (0.9)

4 (3.3)

0 (0)

0 (0)

0 (0)

1 (50.0)

25 (3.1)

2 (0.6)

HPV 11

2 (3.0)

2 (1.0)

2 (0.8)

3 (1.3)

0 (0)

0 (0)

0 (0)

0 (0)

0 (0)

0 (0)

9 (1.1)

0 (0)

HPV 16

20 (30.3)

126 (60.9)

136 (51.9)

113 (48.1)

117 (55.2)

64 (52.9)

18 (43.9)

4 (36.4)

3 (60.0)

1 (50.0)

436 (54.2)

166 (46.5)

HPV 18

9 (13.6)

12 (5.8)

16 (6.1)

36 (15.3)

25 (11.8)

21 (17.4)

5 (12.2)

1 (9.1)

1 (9.1)

0 (0)

73 (9.1)

53 (14.8)

HPV 26

0 (0)

0 (0)

1 (0.4)

0 (0)

0 (0)

1 (0.8)

0 (0)

0 (0)

0 (0)

0 (0)

1 (0.1)

1 (0.3)

HPV 31

5 (7.6)

7 (3.4)

17 (6.5)

22 (9.4)

19 (9.0)

3 (2.5)

5 (12.2)

1 (9.1)

0 (0)

0 (0)

44 (5.5)

35 (9.8)

HPV 33

9 (13.6)

11 (5.3)

21 (8.0)

16 (6.8)

20 (9.4)

7 (5.8)

3 (7.3)

1 (9.1)

1 (20.0)

0 (0)

53 (6.6)

36 (10.1)

HPV 35

1 (1.5)

3 (1.4)

9 (3.4)

8 (3.4)

3 (1.4)

2 (1.7)

2 (4.9)

1 (9.1)

0 (0)

0 (0)

19 (2.4)

10 (2.8)

HPV 39

1 (1.5)

5 (1.5)

13 (2.4)

7 (5.0)

4 (3.0)

2 (1.9)

2 (1.7)

1 (4.9)

0 (0)

0 (0)

21 (2.6)

14 (3.9)

HPV 41

0 (0)

1 (0.5)

1 (0.4)

0 (0)

0 (0)

1 (0.8)

0 (0)

0 (0)

0 (0)

0 (0)

3 (0.4)

0 (0)

HPV 42

2 (3.0)

1 (0.5)

0 (0)

0 (0)

0 (0)

2 (1.7)

0 (0)

0 (0)

0 (0)

0 (0)

4 (0.5)

1 (0.3)

HPV 45

1 (1.5)

1 (0.5)

1 (0.4)

0 (0)

1 (0.5)

2 (1.7)

1 (2.4)

1 (9.1)

0 (0)

0 (0)

4 (0.5)

4 (1.1)

HPV 51

1 (1.5)

2 (1.0)

3 (1.1)

1 (0.4)

1 (0.5)

0 (0)

0 (0)

0 (0)

0 (0)

0 (0)

5 (0.6)

3 (0.8)

HPV 52

2 (3.0)

3 (3.0)

3 (1.4)

3 (1.1)

2 (1.3)

0 (0)

0 (0)

0 (0)

0 (0)

0 (0)

8 (1.0)

5 (1.4)

HPV 53

3 (4.5)

4 (1.9)

9 (3.4)

3 (1.3)

2 (0.9)

2 (1.7)

2 (4.9)

1 (9.1)

0 (0)

0 (0)

20 (2.5)

6 (1.7)

HPV 56

1 (1.5)

5 (0.4)

4 (1.5)

4 (1.7)

3 (1.4)

3 (2.5)

1 (2.4)

0 (0)

0 (0)

0 (0)

16 (2.0)

5 (1.4)

HPV 58

2 (3.0)

4 (1.9)

3 (1.1)

5 (2.1)

2 (0.9)

3 (2.5)

0 (0)

0 (0)

0 (0)

0 (0)

16 (2.0)

3 (0.8)

HPV 59

1 (1.5)

2 (1.0)

2 (0.8)

1 (0.4)

1 (0.5)

0 (0)

0 (0)

0 (0)

0 (0)

0 (0)

6 (0.7)

1 (0.3)

HPV 61

0 (0)

1 (0.5)

1 (0.4)

2 (0.9)

0 (0)

1 (0.8)

0 (0)

0 (0)

0 (0)

0 (0)

4 (0.5)

1 (0.3)

HPV 62

0 (0)

2 (1.0)

1 (0.4)

2 (0.9)

1 (0.5)

0 (0)

0 (0)

0 (0)

0 (0)

0 (0)

5 (0.6)

1 (0.3)

HPV 66

2 (3.0)

6 (2.9)

2 (0.8)

3 (1.3)

3 (1.4)

0 (0)

0 (0)

0 (0)

0 (0)

0 (0)

12 (1.5)

4 (1.1)

HPV 68

1 (1.5)

3 (1.4)

3 (1.1)

2 (0.9)

5 (2.4)

2 (1.7)

2 (4.9)

0 (0)

0 (0)

0 (0)

14 (1.7)

4 (1.1)

HPV 69

0 (0)

2 (1.0)

1 (0.4)

2 (0.9)

1 (0.5)

1 (0.8)

0 (0)

0 (0)

0 (0)

0 (0)

5 (0.6)

2 (0.6)

HPV 74

1 (1.5)

0 (0)

0 (0)

0 (0)

0 (0)

0 (0)

0 (0)

0 (0)

0 (0)

0 (0)

1 (0.1)

0 (0)

HPV 93

0 (0)

0 (0)

1 (0.4)

0 (0)

0 (0)

0 (0)

0 (0)

0 (0)

0 (0)

0 (0)

1 (0.1)

0 (0)

  1. *The data are presented as numbers (%).
  2. †No significant differences found in the age-related distribution patterns of the 25 HPV genotypes, χ2 = 217.4, p = 0.461, two-sided χ2 test.
  3. ‡Significant difference found between the episomal and integrated/mixed infection rates of the 25 HPV genotypes, χ2 = 47.3, p = 0.003, two-sided χ2 test.
  4. §DIPS cannot differentiate the mixed HPV infection cases from the integrated infection cases.
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Journal of Translational Medicine

ISSN: 1479-5876

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