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Table 2 The age-related distributional characteristics and physical statuses of the 25 HPV genotypes detected*

From: Diagnosis of 25 genotypes of human papillomaviruses for their physical statuses in cervical precancerous/cancerous lesions: a comparison of E2/E6E7 ratio-based vs. multiple E1-L1/E6E7 ratio-based detection techniques

HPV genotypes Age groups (years) Physical statuses
20-24 (n = 66) 25-29 (n = 207) 30-34 (n = 262) 35-39 (n = 235) 40-44 (n = 212) 45-49 (n = 121) 50-54 (n = 41) 55-59 (n = 11) 60-64 (n = 5) 65-69 (n = 2) Episomal (n = 805) Integrated/Mixed§(n = 357)
HPV 6 2 (3.0) 4 (1.9) 12 (4.6) 2 (0.9) 2 (0.9) 4 (3.3) 0 (0) 0 (0) 0 (0) 1 (50.0) 25 (3.1) 2 (0.6)
HPV 11 2 (3.0) 2 (1.0) 2 (0.8) 3 (1.3) 0 (0) 0 (0) 0 (0) 0 (0) 0 (0) 0 (0) 9 (1.1) 0 (0)
HPV 16 20 (30.3) 126 (60.9) 136 (51.9) 113 (48.1) 117 (55.2) 64 (52.9) 18 (43.9) 4 (36.4) 3 (60.0) 1 (50.0) 436 (54.2) 166 (46.5)
HPV 18 9 (13.6) 12 (5.8) 16 (6.1) 36 (15.3) 25 (11.8) 21 (17.4) 5 (12.2) 1 (9.1) 1 (9.1) 0 (0) 73 (9.1) 53 (14.8)
HPV 26 0 (0) 0 (0) 1 (0.4) 0 (0) 0 (0) 1 (0.8) 0 (0) 0 (0) 0 (0) 0 (0) 1 (0.1) 1 (0.3)
HPV 31 5 (7.6) 7 (3.4) 17 (6.5) 22 (9.4) 19 (9.0) 3 (2.5) 5 (12.2) 1 (9.1) 0 (0) 0 (0) 44 (5.5) 35 (9.8)
HPV 33 9 (13.6) 11 (5.3) 21 (8.0) 16 (6.8) 20 (9.4) 7 (5.8) 3 (7.3) 1 (9.1) 1 (20.0) 0 (0) 53 (6.6) 36 (10.1)
HPV 35 1 (1.5) 3 (1.4) 9 (3.4) 8 (3.4) 3 (1.4) 2 (1.7) 2 (4.9) 1 (9.1) 0 (0) 0 (0) 19 (2.4) 10 (2.8)
HPV 39 1 (1.5) 5 (1.5) 13 (2.4) 7 (5.0) 4 (3.0) 2 (1.9) 2 (1.7) 1 (4.9) 0 (0) 0 (0) 21 (2.6) 14 (3.9)
HPV 41 0 (0) 1 (0.5) 1 (0.4) 0 (0) 0 (0) 1 (0.8) 0 (0) 0 (0) 0 (0) 0 (0) 3 (0.4) 0 (0)
HPV 42 2 (3.0) 1 (0.5) 0 (0) 0 (0) 0 (0) 2 (1.7) 0 (0) 0 (0) 0 (0) 0 (0) 4 (0.5) 1 (0.3)
HPV 45 1 (1.5) 1 (0.5) 1 (0.4) 0 (0) 1 (0.5) 2 (1.7) 1 (2.4) 1 (9.1) 0 (0) 0 (0) 4 (0.5) 4 (1.1)
HPV 51 1 (1.5) 2 (1.0) 3 (1.1) 1 (0.4) 1 (0.5) 0 (0) 0 (0) 0 (0) 0 (0) 0 (0) 5 (0.6) 3 (0.8)
HPV 52 2 (3.0) 3 (3.0) 3 (1.4) 3 (1.1) 2 (1.3) 0 (0) 0 (0) 0 (0) 0 (0) 0 (0) 8 (1.0) 5 (1.4)
HPV 53 3 (4.5) 4 (1.9) 9 (3.4) 3 (1.3) 2 (0.9) 2 (1.7) 2 (4.9) 1 (9.1) 0 (0) 0 (0) 20 (2.5) 6 (1.7)
HPV 56 1 (1.5) 5 (0.4) 4 (1.5) 4 (1.7) 3 (1.4) 3 (2.5) 1 (2.4) 0 (0) 0 (0) 0 (0) 16 (2.0) 5 (1.4)
HPV 58 2 (3.0) 4 (1.9) 3 (1.1) 5 (2.1) 2 (0.9) 3 (2.5) 0 (0) 0 (0) 0 (0) 0 (0) 16 (2.0) 3 (0.8)
HPV 59 1 (1.5) 2 (1.0) 2 (0.8) 1 (0.4) 1 (0.5) 0 (0) 0 (0) 0 (0) 0 (0) 0 (0) 6 (0.7) 1 (0.3)
HPV 61 0 (0) 1 (0.5) 1 (0.4) 2 (0.9) 0 (0) 1 (0.8) 0 (0) 0 (0) 0 (0) 0 (0) 4 (0.5) 1 (0.3)
HPV 62 0 (0) 2 (1.0) 1 (0.4) 2 (0.9) 1 (0.5) 0 (0) 0 (0) 0 (0) 0 (0) 0 (0) 5 (0.6) 1 (0.3)
HPV 66 2 (3.0) 6 (2.9) 2 (0.8) 3 (1.3) 3 (1.4) 0 (0) 0 (0) 0 (0) 0 (0) 0 (0) 12 (1.5) 4 (1.1)
HPV 68 1 (1.5) 3 (1.4) 3 (1.1) 2 (0.9) 5 (2.4) 2 (1.7) 2 (4.9) 0 (0) 0 (0) 0 (0) 14 (1.7) 4 (1.1)
HPV 69 0 (0) 2 (1.0) 1 (0.4) 2 (0.9) 1 (0.5) 1 (0.8) 0 (0) 0 (0) 0 (0) 0 (0) 5 (0.6) 2 (0.6)
HPV 74 1 (1.5) 0 (0) 0 (0) 0 (0) 0 (0) 0 (0) 0 (0) 0 (0) 0 (0) 0 (0) 1 (0.1) 0 (0)
HPV 93 0 (0) 0 (0) 1 (0.4) 0 (0) 0 (0) 0 (0) 0 (0) 0 (0) 0 (0) 0 (0) 1 (0.1) 0 (0)
  1. *The data are presented as numbers (%).
  2. No significant differences found in the age-related distribution patterns of the 25 HPV genotypes, χ2 = 217.4, p = 0.461, two-sided χ2 test.
  3. Significant difference found between the episomal and integrated/mixed infection rates of the 25 HPV genotypes, χ2 = 47.3, p = 0.003, two-sided χ2 test.
  4. §DIPS cannot differentiate the mixed HPV infection cases from the integrated infection cases.