The relationship between cervical lesions and HPV integration. A. The age-related distribution patterns of cervical lesions (upper panel) and HPV integration events (lower panel, detected with DIPS) in the enrolled women. A significant time retardation was observed between women with cervical precancerous/cancerous lesions and those without lesions as well as between women with cervical integrated/mixed HPV infections and those with episomal infections. B. The cervical lesion-related distribution pattern of HPV integration is displayed. C. The relationship between the HPV integration rate and its tumorigenic rates was analyzed using the Pearson's product–moment correlation coefficient, r. Blue line, the linear fitting curve.