Figure 4
From: let-7b/g silencing activates AKT signaling to promote gastric carcinogenesis
AKT2 is over-expressed in gastric cancer. (A) The expression of AKT2 mRNA in 9 gastric cancer cell lines compared with normal gastric tissue. (B) AKT2 mRNA showed increased expression in gastric tumor tissues compared with adjacent non-cancerous tissues (n = 28, P = 0.034). (C) Western blot analysis of AKT2 in 9 gastric cancer cell lines and 3 normal gastric tissues. (D) The protein expression of AKT2 in 28 paired primary tumors (N, paired non-tumorous tissue; T, tumor tissue). The AKT2 protein expression in gastric cancer tissues was up-regulated compared with adjacent non-tumorous tissues by quantification (P = 0.001). (E) AKT2 mRNA expression showed negative correlation with let-7b/g expression in primary tumors (n = 28; let-7b, P = 0.001; let-7g, P = 0.021).