Figure 5
TNC-1 cells modulate the sensitivity of Doxorubicin to GBM tumor cells. A, B and C: TNC-1 attenuated the response of U251 and LN18 to Doxorubicin at the concentration of 0.5, 1 and 2 μM. HF66 seemed to be protected by TNC-1 at different concentration of doxorubicin, but not significant (p > 0.05) except at the concentration of 1 μM (p < 0.05). D, E and F: TNC1 has no effect on C6, A172 and P3 tumor cells. However, with increasing concentrations of TMZ more A172 cells were eliminated in the presence of TNC-1 compared to spheroids of tumor cells only.