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Table 5 New manufacturing method: improved product purity

From: Bone marrow-derived cells for cardiovascular cell therapy: an optimized GMP method based on low-density gradient improves cell purity and function

 

% Lymphocytes

% Monocytes

% MNC

% Granulocytes

PLT/WBC

Current Method (n = 43)a

48 ± 13 (21-71)

9 ± 3 (5-15)

57 ± 15 (26-84)

43 ± 14 (16-74)

6 ± 5 (1-28)

New Method (n = 24)b

52 ± 11 (34-69)

15 ± 4 ** (8-22)

66 ± 11** (42-85)

34 ± 11** (15-58)

5 ± 2 (2-10)

  1. Data are reported as mean + standard deviation (range).
  2. MNC: Mononuclear cells (lymphocytes +μmonocytes); PLT: Platelets; WBC: White Blood Cells.
  3. ailiac crest (n = 33) and sternal (n = 10) bone marrow samples; bsternal samples only; **p < 0.01 (unpaired T-test).