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Table 4 New manufacturing method overall efficiency: improved contaminants' removal

From: Bone marrow-derived cells for cardiovascular cell therapy: an optimized GMP method based on low-density gradient improves cell purity and function

 

% PLT removal

% GRA removal

% MNC yield

Current method (n = 43)a

89 ± 7

91 ± 4

25 ± 11

New method (n = 24)b

97 ± 1**

95 ± 3**

13 ± 7**

  1. Data are reported as mean ± standard deviation.
  2. PLT: Platelets; GRA: Granulocytes; MNC: Mononuclear cells (lymphocytes +μmonocytes).
  3. ailiac crest samples (n = 33) + sternal samples (n = 10); bsternal samples only; **p < 0.01 (unpaired T-test).