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Figure 2 | Journal of Translational Medicine

Figure 2

From: Systems level mapping of metabolic complexity in Mycobacterium tuberculosis to identify high-value drug targets

Figure 2

Metabolic visualization through Systems Biology Spindle Map ( SBSM). A) Conceptual formulation of SBSM representing the connection between exchange reactions, metabolites, genes and reactions; B) SBSM of Mtb representing its complete metabolic topology based upon the relationships between its biochemical, genomic and genetic information; C) Metabolite gene connectivity (metGene) distribution. Overall connectivity versus the connectivity of utilized metabolites in optimal metabolic physiology; D) Power law distribution of overall connectivity of metabolites to genes in SBSM; E) Power law distribution of active metabolite connectivity to genes in optimal SBSM F) Gene reaction (geneRxn) connectivity distribution. Overall connectivity versus the connectivity of utilized genes; G) Reaction gene (rxnGene) connectivity distribution. Overall connectivity versus the connectivity of active reactions H) optimal metabolic physiology obtained by optimizing for defined biomass function using Middlebrook media.

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