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Table 3 Immune-related response criteria (irRC)

From: Radiotherapy as an immunological booster in patients with metastatic melanoma or renal cell carcinoma treated with high-dose Interleukin-2: evaluation of biomarkers of immunologic and therapeutic response

Index lesions

Non-index lesions

New measurable lesions

New non -measurable lesions

% Change in tumor burden

Overall irRC response

CR

CR

No

No

−100%

irCR

PR

Any

Any

Any

≥ −50%

irPR

PR

Any

Any

Any

< −50% to < +25%

irSD

PR

Any

Any

Any

≥ +25%

irPD

SD

Any

Any

Any

< −50% to < +25%

irSD

SD

Any

Any

Any

≥ +25%

irPD

PD

Any

Any

Any

≥ +25%

irPD

SD

Any

Any

Any

< −50% to < +25%

irSD

SD

Any

Any

Any

≥ +25%

irPD

PD

Any

Any

Any

≥ +25%

irPD

  1. irRC: Immune-related response criteria; CR: Complete response; PR: Partial response; SD: Stable disease; PD: Progressive disease.