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Table 3 Immune-related response criteria (irRC)

From: Radiotherapy as an immunological booster in patients with metastatic melanoma or renal cell carcinoma treated with high-dose Interleukin-2: evaluation of biomarkers of immunologic and therapeutic response

Index lesions Non-index lesions New measurable lesions New non -measurable lesions % Change in tumor burden Overall irRC response
CR CR No No −100% irCR
PR Any Any Any ≥ −50% irPR
PR Any Any Any < −50% to < +25% irSD
PR Any Any Any ≥ +25% irPD
SD Any Any Any < −50% to < +25% irSD
SD Any Any Any ≥ +25% irPD
PD Any Any Any ≥ +25% irPD
SD Any Any Any < −50% to < +25% irSD
SD Any Any Any ≥ +25% irPD
PD Any Any Any ≥ +25% irPD
  1. irRC: Immune-related response criteria; CR: Complete response; PR: Partial response; SD: Stable disease; PD: Progressive disease.