Molecule of interest | Hypoxia preconditioning(1-2%O2) | Inflammatory stimuli(INF-γ, TNF-α, LPS) | 3D culture configuration(microcarriers,microspheres) |
---|---|---|---|
FGF | ↑ |  |  |
VEGF | ↑ | ↑ |  |
IGF | ↑ |  |  |
HGF | ↑ | ↑ |  |
IDO | ↑ | ↑ |  |
Oct 4 | ↑ |  |  |
Rex 1 | ↑ |  |  |
TGF- ↑ |  | ↑ |  |
PGE2 |  | ↑ | ↑ |
BMP2 |  | ↑ |  |
Factor H |  | ↑ |  |
Gal - 9 |  | ↑ |  |
TSG - 6 |  |  | ↑ |
STC - 1 |  |  | ↑ |
CXCR4 |  |  | ↑ |
TRAIL |  |  | ↑ |
IL - 24 |  |  | ↑ |
CD82 |  |  | ↑ |
Secretion of microvesicles/ exosomes |  | ↑ |  |
MSC or MSC – CM effect on other cells | |||
CXCL2 |  |  | ↑ |
TNF - α |  |  | ↓ |
IL - 6 |  |  | ↓ |
IL12p40 |  |  | ↓ |
IL23 |  |  | ↓ |
T - cell proliferation | ↓ | ↓ |  |
CD31 + | ↑ |  |  |
αSMA + desmin + | ↑ |  |  |