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Table 1 Summary of MSC secreted factors induced by Hypoxia, Inflammatory Stimuli and 3- dimensional culture conditions and their effect on other cells

From: A review of therapeutic effects of mesenchymal stem cell secretions and induction of secretory modification by different culture methods

Molecule of interest

Hypoxia preconditioning(1-2%O2)

Inflammatory stimuli(INF-γ, TNF-α, LPS)

3D culture configuration(microcarriers,microspheres)

FGF

↑

  

VEGF

↑

↑

 

IGF

↑

  

HGF

↑

↑

 

IDO

↑

↑

 

Oct 4

↑

  

Rex 1

↑

  

TGF- ↑

 

↑

 

PGE2

 

↑

↑

BMP2

 

↑

 

Factor H

 

↑

 

Gal - 9

 

↑

 

TSG - 6

  

↑

STC - 1

  

↑

CXCR4

  

↑

TRAIL

  

↑

IL - 24

  

↑

CD82

  

↑

Secretion of microvesicles/ exosomes

 

↑

 

MSC or MSC – CM effect on other cells

CXCL2

  

↑

TNF - α

  

↓

IL - 6

  

↓

IL12p40

  

↓

IL23

  

↓

T - cell proliferation

↓

↓

 

CD31 +

↑

  

αSMA + desmin +

↑

  
  1. ↑ = upregulated or stimulated; ↓= down-regulated or non-stimulated.