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Table 1 Summary of MSC secreted factors induced by Hypoxia, Inflammatory Stimuli and 3- dimensional culture conditions and their effect on other cells

From: A review of therapeutic effects of mesenchymal stem cell secretions and induction of secretory modification by different culture methods

Molecule of interest Hypoxia preconditioning(1-2%O2) Inflammatory stimuli(INF-γ, TNF-α, LPS) 3D culture configuration(microcarriers,microspheres)
FGF   
VEGF  
IGF   
HGF  
IDO  
Oct 4   
Rex 1   
TGF-   
PGE2  
BMP2   
Factor H   
Gal - 9   
TSG - 6   
STC - 1   
CXCR4   
TRAIL   
IL - 24   
CD82   
Secretion of microvesicles/ exosomes   
MSC or MSC CM effect on other cells
CXCL2   
TNF - α   
IL - 6   
IL12p40   
IL23   
T - cell proliferation  
CD31 +   
αSMA + desmin +   
  1. ↑ = upregulated or stimulated; ↓= down-regulated or non-stimulated.